概述
Ewing sarcoma is a rare and aggressive cancer that forms in the bone or soft tissue, most commonly in children and adolescents. It usually affects the pelvis, femur, ribs, and chest wall.
症状
- Pain or swelling at the tumor site
- Fever or fatigue
- Bone fracture with minor trauma
- Limping or decreased movement
病因与风险因素
- Exact cause unknown; associated with a chromosomal translocation (EWSR1-FLI1)
- Most common in children and teenagers
- Slight male predominance
- Not strongly linked to inherited genetic syndromes
诊断方法
- X-ray, MRI, or CT of affected area
- Biopsy with cytogenetic testing
- Bone scan or PET-CT
- Bone marrow biopsy (to rule out spread)
治疗方案
- Neoadjuvant chemotherapy (initial systemic treatment)
- Surgical resection (limb-sparing or resection of affected bone)
- Radiation therapy (if surgery is not feasible or for residual disease)
- Adjuvant chemotherapy (after local treatment)
预后情况
- 5-year survival for localized disease: ~70%
- Worse prognosis for metastatic or relapsed disease
- Prognosis improves with good chemotherapy response and complete surgical resection
与此类癌症共处
- Physical rehabilitation and growth support (in young children)
- Psychosocial support and peer integration
- Long-term monitoring for late effects of chemotherapy and recurrence
预防与筛查
- No known prevention methods
- No standard screening; early evaluation of persistent bone pain is key
FAQs
Q: Is Ewing sarcoma a childhood cancer?
A: Yes, most commonly occurs in people under 20 years old.
Q: Can it be cured?
A: Yes, especially if localized and treated aggressively with chemo and surgery.
Q: Does it affect growth?
A: It may, especially if the growth plates are involved or due to treatment effects.
相关资源
- CureSearch for Children’s Cancer
- American Cancer Society
- ClinicalTrials.gov
