Myeloproliferative neoplasms (MPNs) are a group of chronic blood cancers where the bone marrow makes too many red cells, white cells, or platelets. They are linked to mutations in genes such as JAK2, CALR, and MPL, and may remain stable for years or progress to myelofibrosis or acute leukemia.
The three main types of classic MPNs are:
• Polycythemia vera (PV) – too many red blood cells
• Essential thrombocythemia (ET) – too many platelets
• Primary myelofibrosis (PMF) – scarring of the bone marrow
