Oxaliplatin is a chemotherapy medication primarily used in the treatment of colorectal cancer, often in combination with other drugs such as 5-fluorouracil.

It belongs to the platinum-based class of chemotherapy agents.

Oxaliplatin works by forming cross-links within DNA strands in cancer cells, which may disrupt DNA replication and transcription. This may inhibit cancer cell growth and lead to cell death.

In addition to common chemotherapy-related side effects, oxaliplatin is known to be associated with nerve-related symptoms, such as sensitivity to cold or tingling sensations, due to its effects on nerve cells.