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Immuneframe

Understand Your Immune System

The Immune-Frame test is a specialized laboratory test intended for informational and research purposes only. It is not designed to diagnose, treat, or cure any disease. All test results should be interpreted by a qualified healthcare professional in the context of the patient’s overall medical history. Individuals should not make medical decisions or changes to treatment based solely on this test. Always consult your physician or specialist before taking or acting on any medical test.

A Deep Dive Into Your Immune Health

Immune-Frame is a powerful diagnostic tool that assesses your immune system to guide treatment and identify hidden health risks.

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What Is Immune-Frame?

Immune-Frame is a diagnostic test that evaluates the condition of a patient’s immune system by identifying key cellular markers responsible for immune activation or suppression. Using advanced techniques like ELISA and flow cytometry, the test provides insights into immune balance, highlighting overactive or suppressed responses. Clinicians use this data to assess immune health, guide treatment decisions, and identify potential health risks early.

Test Details

Sample type

Whole peripheral blood sample

Analysis period

Approx. 7 business days

Final results

7-10 business days after sample delivery

Sample size

15-25 ml peripheral whole blood

What we looking at?

For Practitioners
For Patients

Who Should Take This Test – Scientific Rationale

  • Cancer patients
  • Autoimmune conditions
  • Chronic infections
  • Recurrent illness
  • Patients undergoing immunotherapy
  • General immune assessment
A. Cancer Patients
Why: Cancer can suppress the immune system and promote chronic inflammation that helps tumors grow. Immune-Frame detects markers that are related to immune suppression or tumor-driven inflammation, guiding immunotherapy decisions and helping doctors monitor treatment response or identify immune dysfunction early.

How Immune-Frame Helps: The test detects immune suppression or immune exhaustion, helping assess whether the immune system is actively fighting the tumor or being suppressed by it. It also provides a baseline before immunotherapy or chemotherapy.

B. Patients with Autoimmune Conditions
Why: Autoimmune diseases are characterized by an overactive or misdirected immune response, where the body attacks its own tissues.

How Immune-Frame Helps: The test detects cytokine imbalances (e.g., elevated IL-4, IL-6, or TNF-α) and abnormalities in T-cell regulation, which are central to autoimmune activity. This helps in monitoring disease activity and adjusting immunosuppressive therapies.

C. Patients with Chronic Infections
Why: In persistent infections (e.g., HIV, EBV, hepatitis), the immune system can become chronically activated or exhausted, reducing its effectiveness.

How Immune-Frame Helps: It assesses cytokine levels and immune cell activation markers to determine whether the immune system is stuck in a suppressed or over-activated state, guiding antiviral strategies or supportive immune therapy.

D. People with Recurrent Illness or Fatigue
Why: Frequent infections or unexplained fatigue may be signs of immune dysfunction (either deficiency or chronic inflammation).

How Immune-Frame Helps: It identifies under-functioning immune pathways (e.g., low IFN-γ, IL-2) or inappropriate activation (e.g., elevated IL-6) to uncover hidden immune deficiencies or chronic inflammation.

E. Patients Undergoing Immunotherapy
Why: Immune checkpoint inhibitors and other immunotherapies rely on the presence of functionally active T-cells to attack tumors. Some patients may not respond due to immune suppression.

How Immune-Frame Helps: The test evaluates baseline immune readiness and detects suppressive markers (like CTLA-4) to help predict responsiveness to immunotherapy or monitor immune-related adverse events.

F. General Immune Assessment / Preventive Health
Why: In preventive or integrative medicine, understanding immune status is crucial for optimizing long-term health and resilience.

How Immune-Frame Helps: It provides a snapshot of immune balance, useful for tailoring nutrition, supplements, or lifestyle interventions in healthy individuals or those with risk factors.

G. Patients Undergoing Cell-Based Therapies (Stem Cell, NK Cell, Dendritic Cell Therapies)
Why: Cell therapies rely on a functioning and responsive immune environment to be effective. However, immune suppression, chronic inflammation, or immune exhaustion can reduce the efficacy of these therapies. Without understanding the patient’s baseline immune condition, it's difficult to predict or optimize treatment outcomes.

How Immune-Frame Helps: Prior to therapy, Immune-Frame provides a comprehensive baseline of the patient’s immune status. Following treatment, measurable changes such as increases or decreases in specific immune markers can offer insights into the therapy’s biological impact and support clinical decision-making. Examples:

‧ Dendritic cell therapy should raise costimulatory markers like CD80/CD86, indicating maturation and improved Tcell activation

‧ Mesenchymal stem cell (MSC) therapy is anti-inflammatory / anti-aging. MSCs have anti-aging effects by modulating chronic inflammation (“inflammaging”), promoting tissue repair, and rejuvenating aged immune system. They secrete anti-inflammatory molecules, shifting macrophages to an anti-inflammatory M2 phenotype and suppressing inflammaging

Oncotrail has undergone rigorous evaluation to ensure high sensitivity and specificity, making it an invaluable tool for diagnostic purposes.

Through high-precision techniques, the test is used to monitor the effectiveness of a particular cancer treatment. This would objectively provide information on how well the treatment is going.

The non-invasive tracking of the cancer status would notify a treating physician whether to adjust current management or stay the course. This would be important to know in almost real-time rather than to find out much later that a treatment doesn't apply to a particular person.

This allows practitioners to optimize dosing or timing, ensuring the therapy is effective and tailored per patient response.

How the Test Works

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1. Blood collection

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2. Lab analysis (ELISA + flow cytometry)

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3. Report generation

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4. Clinical interpretation

  • Brief step-by-step process

Benefits of Immune-Frame

Tailored to both patients and clinicians:

Personalized health insights:

Immune-Frame offers a snapshot of an individual’s immune function by analyzing specific markers involved in immune activation, suppression, and inflammation. For patients, this provides clear insights into their current immune status; for clinicians, it allows the development of individualized care plans based on each patient’s immune profile.

Supports treatment decisions:

By identifying immune imbalances—such as suppressed T-cell activity, elevated pro-inflammatory cytokines, or overactive regulatory pathways—clinicians can adjust therapies (conventional or natural), determine timing for immunotherapies or cell-based treatments, and monitor response. This enhances clinical precision and reduces guesswork.

Non-Invasive and Scientifically Validated:

The test only requires a standard blood sample, making it non-invasive for patients. It uses validated methods like ELISA and flow cytometry, and measures clinically relevant immune markers, providing robust data that supports evidence-based decision-making.

Dr. Sarah Khong
M.D.
Director of Physician Development & Network Engagement

Take Control of Your Immune Health

To learn more about the test, its clinical uses, or how to interpret results, please reach out to our team.

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Download sample report and immuneframe guide

Download sample report
Download immuneframe guide